Launched in 2018. It's 2022 and PySimpleGUI is actively developed & supported. Create complex windows simply. Supports tkinter, Qt, WxPython, Remi (in browser). Create GUI applications trivially with a full set of widgets. Multi-Window applications are also simple. 3.4 to 3.11 supported. 325+ Demo programs & Cookbook for rapid start. Extensive documentation. Examples for Machine Learning(OpenCV Integration, Chatterbot), Rainmeter-like Desktop Widgets, Matplotlib + Pyplot integration, add GUI t
I would stick with pySimpleGui until you find a requirement that it can't fulfill. At least skinning should be possible, see for example https://github.com/PySimpleGUI/PySimpleGUI/issues/3412 with loads of examples.
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
Dear PyGui is a GUI framework that seems to be increasingly popular with engineers and scientists. Obviously, it depends on your requirements. PyQt/Pyside and Electron are probably the most mature libraries with their own strengths. Potential downside to PyQt/Pyside is the license. Electron GUI is most like the web. Downside is the library size as it basically includes Chromium.
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