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Nuitka
Nuitka is a Python compiler written in Python. It's fully compatible with Python 2.6, 2.7, 3.4, 3.5, 3.6, 3.7, 3.8, 3.9, 3.10, and 3.11. You feed it your Python app, it does a lot of clever things, and spits out an executable or extension module.
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nuitka is really good
There is however a python-nogill fork of cpython https://github.com/colesbury/nogil
Well not quite FROM scratch (you still need an interpreter installed) but you can use pex to package up executables into distributable “binaries” prepackaged with a venv and all your deps. Bonus points for using pants to manage it all.
The main point of contention seems to be PEP 631's dependency specification. However, I am not sure what exact problems Poetry has with it. There's a discussion here.
It’s been implemented into a C library: Cosmopolitan