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Yes, renpy is fine to use. Just make sure to download it through the official website and you'll be fine. There have been issues with false positives on antivirus recently (just search for "virus" on here), so that's the reasons for the posts. You can see the bug report here.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.