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He's wrong about Linux, it's possible to build Linux-based unikernels: https://github.com/unikernelLinux/linux
Hey, Unikraft has support for running the Python[0] and Ruby[1] runtimes as unikernels. We're about to release PHP too :) Watch this space!
A bit OT: what kind of performance do you normally expect from OCaml? I looked at the Prime Sieve challenge[1] recently and with the current submissions the Standard ML solution is 3 times faster than the OCaml one. I've also spent some time optimizing this SML solution and got it several times faster still. With a bit more work I thinkg I could get it up to the speed of the fastest C solution. It's compiled with MLton. From that POV OCaml is a bit disappointing, since I've also viewed SML as a "hipster language" that hasn't had that much money put into it, while OCaml saw quite a bit more development, so I would expect the OCaml compiler to be able to produce better code. I've briefly looked at the OCaml code, but I don't know OCaml as much as SML, so can't really say what may be the issue in the OCaml case.
[1]: <https://plummerssoftwarellc.github.io/PrimeView/report?id=rb...>
Great entrant in the space that is actually usable:
Promising project that's inactive but was one of the first ones I found with reasonable ergonomics and no lock-in to a specific language that I didn't use:
https://github.com/rumpkernel/rumprun
Unfortunately it looks to be unmaintained as of now, but I expect the examples still work etc (https://github.com/rumpkernel/rumprun/issues/135)