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MikroORM
TypeScript ORM for Node.js based on Data Mapper, Unit of Work and Identity Map patterns. Supports MongoDB, MySQL, MariaDB, MS SQL Server, PostgreSQL and SQLite/libSQL databases.
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SurveyJS
Open-Source JSON Form Builder to Create Dynamic Forms Right in Your App. With SurveyJS form UI libraries, you can build and style forms in a fully-integrated drag & drop form builder, render them in your JS app, and store form submission data in any backend, inc. PHP, ASP.NET Core, and Node.js.
I guess an example of such implementation would be https://mikro-orm.io/ allows multiple different databases. Always expose same interface, but allows to configure different databases.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.