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Here's the GitHub repo: https://github.com/vendure-ecommerce/vendure
So Vendure is built on top of NestJS, which itself is a TypeScript-based node framework. Both Nest and Vendure make heavy use of typescript features such as decorators. So Vendure is very much aimed primarily at TypeScript, and while you certainly can use JS, it is much clunkier to eg. do the decorators stuff without TS. So I would recommend against it. I guess the main "pro" of JS is that there is no new stuff to learn, and the build pipeline has one fewer steps.
Good point! I probably should have linked this: https://github.com/vendure-ecommerce/vendure-docker-compose