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In a recent project of mine, I wanted to implement few dynamic components, and i really didn't wanted to have a rest arch for this project as i didn't see any strong need for that, In such cases I think something like django unicorn is a really strong contender, as it avoids the pain of writing a separate base for frontend as well as code duplication and redundancy in writing ajax's and templates.
If you are building something that is trying to be the next Facebook where there are lots of components that are working together to build an “app” like experience then a Vue / React frontend can make life way easier when it comes to keeping track of state. It can also make it easier to start building native apps but mostly if you build this in from the start via something like ionic