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About simulation: we do have simulators of brains (to some extent). The main example is the simulation of the C. Elegans. One such simulator is on github at https://github.com/Flowx08/Celegans-simulation
The problem is, well before tackling the human brain - with functional units, wiring, evolutionary rewiring (the human nervous system is also made by "afterthought" increases which overlapped on pre-existing structures patching them, instead of "correcting, reprogramming" them), modules, multiform glias and mysteries in general etc. - that of transparency, i.e. already in the C. Elegans you can see complex behaviour in your artificial being, but the hard and inexahusted part is that of understanding why and how that structure presents that behaviour. It is a problem (the "scientific problem") of understanding the "natural phenomenon" we found, to export that understanding. We know the structure of the C. Elegans since 1985, but we still do not know well "why it works, why it works that way".
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