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Have a look at Flask: https://flask.palletsprojects.com/
Python Fast.API would be my go to for most API purposes: https://fastapi.tiangolo.com/. It allows you to directly return dictionaries and automatically handles proper response types as well as auto-generating basic docs for all of your routes. It’s also extensible enough where you can add in good response validation, which is typically much harder in other micro-frameworks like Flask. If you want to stay on the javascript/node.js side of things, I would take a look at Express.js, which can also be good in many circumstances and is pretty lightweight. I’ve never used nestjs, but Django at least is pretty heavy and more geared towards CMS usage and personally even for that I would stay away from it.