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There is koka which supposedly is higher level (functional), but compiles down to efficient code (I have yet to actually try it, so can't say much more).
These "higher-level" languages have a sharp learning curve (at least initially), the most successful example being Rust.
Another research project that I'm aware of is F*, which has a C backend.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.