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To set things up, first you'll need to install a custom version of SKSE (there is a link to a Google Drive file inside the GitHub link) and a custom version of Proton, the open source software Valve uses to run Windows games on Linux, which is basically Wine with a few other software bundled together, like DXVK.
Currently there are scripts available for both MO2 and Vortex, though the latest one for Vortex on Lutris (1.4.15) is currently broken, the latest working script can be found here: https://github.com/rockerbacon/lutris-skyrimse-installers/releases/tag/1.9.3.
As far as I know, both MO2 and Vortex work. You'll want to install them through Lutris, which is a game library front-end that manages automated install scripts for games, usually through Wine, so you don't have to manually configure Wine for every single game you want to play.
The only two mods I couldn't get working was .Net Framework (it requires .NET48 which is broken on the most recent Wine versions while some things are being refactored in the code) and SmoothCam. Everything else seems to work.