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And indeed, you can see as a great example from the discussion on this thread how they eventually arrived at relying on Rust for most steps in the tsc toolchain: https://github.com/denoland/deno/issues/5432
The conclusion reached there is as you have stated: Rust is simply an order of magnitude faster in most cases.
For reporting issues with Deno Deploy
IMO, one of the coolest features of Deno Deploy is that the deployment primitive is the humble URL, rather than being coupled to git or some git hosting provider.
You can simply give it a URL to a JS file and it will fetch all its dependencies and run it. They also offer an API for triggering deploys programmatically , which you can use to trigger deploys as a step in your CI pipeline for GitLab.
In fact, their GitHub integration is actually just listening for a webhook on new commits to the default branch, and the actual deploy is triggered using the raw.githubusercontent.com URL, so they don't have to waste time cloning the entire repository, which can save on the order of minutes for large repos. 
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Sharpest edge to me is that it's not quiet TypeScript. This means that you can't write a TypeScript file that works in both Deno and regular TypeScript (if you use any imports). Because of the issue that in TypeScript you can't import ".ts" file but you can import ".js" file, whereas in Deno you explicitely import ".ts" files. 
"JSON Web Almost Everything" - JWA, JWS, JWE, JWT, JWK, JWKS for Node.js, Browser, Cloudflare Workers, Deno, Bun, and other Web-interoperable runtimes.
Biggest sharp edge I've encountered is the very much WIP WebCrypto API support. In practical terms, this means things like signing/verifying JWTs is not very well supported: https://github.com/panva/jose/discussions/243
That said, the situation is improving rapidly, and I've been personally willing to bet that the support will be solid by the time I finish prototyping and need to start adding auth to my latest project.
They're not perfectly isolated to a high security standard such that you could deploy your own v8 workers SaaS. And they do have quirks and development woes. I haven't tested in production but if it's just your trusted apps wanting to exceed the cloudflare workers 30 scripts limit then both are wonderfully powerful solutions to put behind a https proxy.
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