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DearPyGui
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
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There are different GUI frameworks for a reason, whether it's the license, performance, what it looks like, ease of use or features. Common desktop GUI frameworks are PyQt/Pyside, Kivy, Tkinter, Dear PyGui. I happen to like Dear PyGui for it's modern look, speed, features and the way it works matches my way of thinking about a GUI.
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NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.