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From the TypeScript team, no. It would break the design goals for the project: https://github.com/microsoft/TypeScript/wiki/TypeScript-Design-Goals
Probably not, but I do have a dream to someday use AssemblyScript output, load that up into something like this: https://github.com/tana/Wasm3DotNet/blob/main/Wasm3DotNetDemo/Program.cs, add some .net library bindings, and have some fun.
there's a nuget WebAssembly package, so you can probably run assemblyscript on .net already.