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There's quite a few API's out there for this. I can't say what would be best but VirusTotal works OK and there are a number of .Net wrappers for it. Owned by Google/Alphabet but surprisingly hasn't been killed off yet. Unless ownership changed which is always possible with them. As someone else mentioned, Cloudmersive is a thing. Haven't tried it though. I've mostly just gone the ClamAV route in the past.
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Hence, a higher number means a more popular project.