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wxGlade
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DearPyGui
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
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Dear PyGui is a great, new Python GUI library. It's fast (written in C++ and GPU based), has a modern look and easy to work with.
Unfortunately no. At least not a designer. If you want to create web GUIs with python you may have a look at https://github.com/flexxui/flexx
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.