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PySimpleGUI
Launched in 2018. It's 2023 and PySimpleGUI is actively developed & supported. Create complex windows simply. Supports tkinter, Qt, WxPython, Remi (in browser). Create GUI applications trivially with a full set of widgets. Multi-Window applications are also simple. 3.4 to 3.11 supported. 325+ Demo programs & Cookbook for rapid start. Extensive docs
The psutil package makes getting a list of running programs not very difficult. There's an example demo program that polls once a second and displays the top process using CPU time. You could use it as a starting point perhaps.
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psgtray
System Tray Icon for PySimpleGUI (the tkinter version). Adds a system tray icon by using pystray and PIL
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