Is it feasible to develop a Substrate blockchain for one of these potential application contexts, and how can I validate it academically using Python simulations and three.js?

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    As /u/t9b said, use case that needs blockchain are limited. And in your context lists, the first two are a big NO to use blockchain to implement them. Contexts 3, 4 and 5 are more suitable, but depends on the requirements. For information, context 3 is similar to what OriginTrail does (https://origintrail.io/), however their blockchain source code is not open source. Context 4 is similar to what Energy Web does (https://www.energyweb.org/).

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