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SurrealDB is written entirely in Rust and it looks pretty promising tbh
RustDesk uses Rust + Flutter for desktop.
One of the bigger desktop GUI Rust application projects of which I'm aware is the Lapce text editor/IDE and it uses a fork of an earlier GUI exploration.
On the "immediate mode" front egui (Showcase gallery) seems to be gaining some level of "critical mass" in terms of uptake which has resulted in quite a wide variety of backend implementations (both "official" & 3rd party). This has had the benefit that you can use egui in a "low dependencies" context but also find it integrations implemented for bigger projects such as Bevy--so it's nice to have the ability to transfer one's egui knowledge into multiple contexts. (egui is also the Rust GUI crate with which I've had the most experience.).
The potential is both in terms of moving away from proprietary corporate-controlled standards (but also still providing shared wrappers to support those "legacy" :) audio plugin formats) and supporting Rust as a first class development language (via e.g. https://github.com/robbert-vdh/nih-plug).