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Latest 5.x beta release was over a year ago https://github.com/expressjs/express/blob/5.0/History.md
There's already qwik, that does SSR and then converts the rest of the app into lazily loaded event handlers.
If you have to do frontend, I would just go with NextJS. It can serve as an API as well. I just came across this today https://sst.dev/ and I'm looking to use that on a side project. It basically runs NextJS or other popular frontend frameworks on AWS using serverless. That way you don't have to worry as much about concurrency.
you should try out https://wasp-lang.dev which is basically Ruby-On-Rails for the React-Express-Postgres (PERN) Stack