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Latest 5.x beta release was over a year ago https://github.com/expressjs/express/blob/5.0/History.md
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There's already qwik, that does SSR and then converts the rest of the app into lazily loaded event handlers.
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Nest
A progressive Node.js framework for building efficient, scalable, and enterprise-grade server-side applications on top of TypeScript & JavaScript (ES6, ES7, ES8) 🚀
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If you have to do frontend, I would just go with NextJS. It can serve as an API as well. I just came across this today https://sst.dev/ and I'm looking to use that on a side project. It basically runs NextJS or other popular frontend frameworks on AWS using serverless. That way you don't have to worry as much about concurrency.
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you should try out https://wasp-lang.dev which is basically Ruby-On-Rails for the React-Express-Postgres (PERN) Stack