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Just remember to use MyPy in strict mode, Ruff, Poetry, and Maturin to keep the Python side of things maintainable.
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CodeRabbit
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I use Qt but I use PyO3 to set up a "Python/PyQt/PySide frontend on top of Rust backend" architecture for the QWidget APIs similar to the "QML frontend on top of C++ backend" that they officially promote for Qt Quick.
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Gtk doesn’t require you to write xml, you can write your gui code in Rust. You also have https://github.com/fltk-rs/fltk-rs
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