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Another possibility that you should definitely look at is AssemblyScript: https://www.assemblyscript.org/ ... I prototyped some stuff with this one, and it was surprisingly capable.
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InfluxDB
Purpose built for real-time analytics at any scale. InfluxDB Platform is powered by columnar analytics, optimized for cost-efficient storage, and built with open data standards.
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AECforWebAssembly
A port of ArithmeticExpressionCompiler from x86 to WebAssembly, so that the programs written in the language can run in a browser. The compiler has been rewritten from JavaScript into C++.
Well, for my programming language, when I wanted to target WebAssembly, I made an entirely new compiler for that.
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I handwrite wasm and then optimize with binaryen (using binaryen for the code generation is terrible DX). Actually I'm working on a small project for the code generation part