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For Node/TS, check out NestJS which provides abstractions that provide a similar experience to building a .NET Core Web API and has integrations with popular ORMs, etc.
.NET Core can absolutely run on Lambda and API Gateway. Check out the demos: https://github.com/aws-samples/serverless-dotnet-demo/. While I haven't actually implemented an AWS API Gateway backed by .NET Core Lambdas with EF Core accessing an RDBMS, a quick internet search shows people using EF Core with Lambdas. Can you point to the documentation you found that said you that EF Core requires trimming? As to Gravitron, I assume you meant AWS Gravitron-processor-backed EC2 (sorry, I'm not that familiar with Gravitron)? Is this a hard requirement? Why do you care about Gravitron?
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