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AreWeAntiCheatYet
A comprehensive and crowd-sourced list of games using anti-cheats and their compatibility with GNU/Linux or Wine.
I am not familiar with that distro at all, so no idea. KDE Plasma is fine, I use it myself (with BSPWM as my window manager, but that's irrelevant)
Personal preference. I use system Wine because launchers are just bloat to me. My distro is Void Linux, so the Wine package from the repos is always up to date. If you use a stable distro like Ubuntu you might want to use a launcher if it gives you access to newer Wine builds.
It's worth checking Are We Anti-Cheat Yet to see which will and won't work.