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If you use nix to manage the packages for a user on a different distro you can use https://github.com/nix-community/home-manager to manage settings and packages declaratively, and then basically you one need to source a single file in your shell profile (or the profile of your de) which sets up the stuff to find the desktop files and more.
On Chrome OS, the instruction is documented at https://nixos.wiki/wiki/Installing_Nix_on_Crostini, but I am using the following home-manager module: https://github.com/akirak/nix-config/blob/cd52178b684664c55ea50159d0f6aa5ea6b1a33e/home/modules/crostini.nix