Top 3 TeX Testing Projects
A Smarter QuickCheck
Test.GenCheck Haskell project
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Increases unit test coverage with fewer test cases using all-pairs and other covering arrays.Project mention: Ask HN: How can I help my devs solve “combinatorial test case scope creep”? | news.ycombinator.com | 2022-01-31
You might find the approach used in UnitTestDesign.jl  to be useful. If I understand it correctly, the package tests combinations where more than one parameter changes, since it assumes this is when breakage is more likely to occur, versus the exhaustive testing you're trying to avoid.
Disclaimer: I haven't actually tried this approach yet.
TeX Testing related posts
What are some of the best open-source Testing projects in TeX? This list will help you: