poly
m4b-tool
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poly | m4b-tool | |
---|---|---|
24 | 34 | |
640 | 1,062 | |
3.1% | - | |
8.2 | 6.8 | |
8 days ago | about 1 month ago | |
Go | PHP | |
MIT License | MIT License |
Stars - the number of stars that a project has on GitHub. Growth - month over month growth in stars.
Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
poly
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GitHub Accelerator: our first cohort and what's next
- https://github.com/TimothyStiles/poly: Poly is a fast, well tested Go package for engineering organisms.
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These 20 startups are in 1st ever batch of GitHub OS Accelerator
Poly: Fast Go package for engineering organisms
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Ask HN: Burnt out from big tech. What's next?
You might want to look at computational biology. Jim Allison won the Nobel Prize back in 2018 for his work on immunotherapy for cancer and there's a lot of basic research work to be done to perfect this approach. Epigenetic clocks are really interesting too (see Steve Horvath's work). Also, there's synthetic biology, where you could, for example, explore this package that's written in Go: https://github.com/TimothyStiles/poly
- Where can I find well-written go code to learn from?
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High-performance language recommendation
Check out poly. It’s written in go and I’m using it for one of my projects too. The goal is that we should have high performance libraries that we can use knowing what people are working on the forks will give the community a leg up.
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How is GO used in bioinfo?
The most popular bioinformatic package I've seen in go is poly.
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Software engineers: consider working on genomics
I write synthetic biology software for a living and maintain this open source, Go package for engineering DNA that has high test coverage and a nice little dev community around it.
https://github.com/TimothyStiles/poly
A large part of my project's community are devs that want to get into the field but can't tolerate the ridiculously low pay, laughably bad management, disrespect, and what amounts to 40+ years of technical debt that's endemic to biotech software.
I've had companies here in the Bay Area offer me 100K a year with a straight face. I've had companies during interview tell me they're looking for someone to help, "set up GitHub". I've seen job listings for low paid web dev positions require applicants to have PhDs.
The reality is that except for a growing handful of places management straight up won't know the difference between IT and software engineers. It's what I call the naive buyers problem.
The demand for software engineers in biotech is generated by naive buyers that don't know what they need, why they need it, or how to get it.
Benchling and Recursion Pharmaceuticals have reputations in the industry of paying, "standard software salaries". So do the research divisions at places like deepmind/microsoft/google but in my experience there's even new multi-billion dollar institutes where senior management has never even heard the term devops.
Most places advertise for "data scientist", positions or some analog, instead of software engineers. This is mostly because upper management has never met an actual practicing software engineer in a professional setting. Many come from academia where the culture and work requirements heavily disincentivize standard software engineering practices.
It's also not uncommon for a biotech company to either have a very under qualified CTO whose main programming experience is what they learned doing ML research like stuff during their PhD or not even have one at all which has huge downstream consequences.
This week a software engineer trying to make the switch to biotech actually DM'd me to ask why they were seeing a ton of data science / ML job positions but no software engineering / devops positions.
They were worried that these companies were trying to save on costs by forcing their data scientists to create infrastructure but it's actually worse than that. Most of these companies aren't even aware that there's supposed to be infrastructure.
Despite all of this the future is looking better and I'm starting to find new companies and positions that are well... reasonable. I learned about this thread from a friend at a party last night that works at one of these companies. There's a small, strong new wave of companies and developers out there pushing biotech software forward. Hopefully some (including myself) make it big while pushing the idea that better tech equals better biotech.
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Ask HN: What interesting problems are you working on? ( 2022 Edition)
A couple of years ago I realized that there weren't any good open source software packages for designing DNA so I wrote one.
https://github.com/TimothyStiles/poly
Goal is to have a suite of packages and databases that can be used to design entirely novel proteins, metabolic pathways, and DNA constructs at scale because right now that software ecosystem just doesn't exist.
It is more like the X Y Z W. However, the X Y Z W bits I am working on as well (https://github.com/TimothyStiles/poly , https://github.com/TimothyStiles/allbase , trilo.bio, freegenes.org). Going for fully automated "make bacterium X produce molecule Y", but still a while away (but surprisingly not THAT far off)
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Ask HN: What's the best source code you've read?
Not that I understand any of the organic science behind it, but Timothy Stiles' Poly is some of the most beautiful Go code I've seen: https://github.com/TimothyStiles/poly
Blew my mind reading through it, honestly. Just perfect.
m4b-tool
- BATCH Merging and converting solution for 3.5 TerraByte Audiobook Library?
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Plex needs an audio book style library
MP3Merge, m4b-tool. This one is interesting for iOS users.
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Best Windows app for combining multiple MP3s into single M4B
Look into m4btool (https://github.com/sandreas/m4b-tool). Audiobookbinder increases the m4b filesize. Followed this post for my own purposes: https://apple.stackexchange.com/questions/426094/convert-multiple-mp3-files-or-single-m4a-into-m4b-with-ffmpeg-and-afconvert
- Which Software to merge mp3 files to audiobook with chapters?
- Ask HN: What interesting problems are you working on? ( 2022 Edition)
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Selfhosted MP3/FLAC Tag editor
I use MusicBrainz Picard in a docker container and can access over web to edit mp3 and flac. But if you use it for audiobooks you should use https://github.com/sandreas/m4b-tool
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Advice on Complex Audiobook
However, I only went through the trouble because I didn't want audio quality to be affected at all (nothing to be encoded again, only removed). If you are not too concerned about audio quality, there is definitely programs out there on Mac that can chapterize files. M4btool is pretty powerful and there is Audiobook converter. I've heard AudioBookBinder might work as well, though I think it is older at this point.
- Does Plex support m4b audiobooks? I have been searching and results say yes, but Plex cannot find any of my books that are m4b only the ones which are mp3
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Ask HN: How do you search for products / apps given a list of requirements?
- LG G5 H850 (optional with Bang & Olufsen Hifi-Plus module) + Audiobookshelf + Substreamer
Let me cite my comment from https://news.ycombinator.com/item?id=32042780:
I use m4b-tool[1], tone[2] and audiobookshelf[3] together with an LG G5 H850 smartphone[8] with Bang & Olufsen Hifi-Plus Module for Audio Only and I am pretty happy with this config. For Music I use Navidrome[5] and Substreamer App[7]. Maybe I'll try out Jellyfin[4] or maybe Plex[6], but I really don't wanna go closed source.
I also thought about writing something self hosted in C# to have ONE solution for audiobooks, podcasts and music and started a small private project, but this will take a while until it is ready to release something...
You may ask: Why an LG G5 H850? Well, its relatively small and cheap (about 50 - 80 bucks used) it has an audio Jack, USB-C, you can change the battery, it can hold up to 2TB microSD storage, has an HiFi Plus module for audio enthusiasts and a descent screen. Besides that it can run lineage os...
Note: I'm the author of the first two projects :-)
[1]: https://github.com/sandreas/m4b-tool
[2]: https://github.com/sandreas/tone
[3]: https://github.com/advplyr/audiobookshelf
[5]: https://www.navidrome.org/
[6]: https://www.plex.tv
- Ask HN: Is there a Calibre equivalent for Audio books?
What are some alternatives?
ffmpeg-python - Python bindings for FFmpeg - with complex filtering support
AudioBookConverter - Improved AudioBookConverter based on freeipodsoftware release (mp3 to m4b converter)
Audiobooks.bundle - Audiobook metadata agent for Plex
Plex-Audiobook-Guide - A walkthrough for optimal Audiobook experience using Plex
jid - json incremental digger
KeenWrite - Free, open-source, cross-platform desktop Markdown text editor with live preview, string interpolation, and math.
tone - tone is a cross platform audio tagger and metadata editor to dump and modify metadata for a wide variety of formats, including mp3, m4b, flac and more. It has no dependencies and can be downloaded as single binary for Windows, macOS, Linux and other common platforms.
ZXing - ZXing ("Zebra Crossing") barcode scanning library for Java, Android
video-everyday - Automatically create a '1 second everyday' video
sysbox - sysadmin/scripting utilities, distributed as a single binary
dockly - Immersive terminal interface for managing docker containers and services
espanso - Cross-platform Text Expander written in Rust