poly VS htmx

- https://github.com/TimothyStiles/poly: Poly is a fast, well tested Go package for engineering organisms.

Poly: Fast Go package for engineering organisms

You might want to look at computational biology. Jim Allison won the Nobel Prize back in 2018 for his work on immunotherapy for cancer and there's a lot of basic research work to be done to perfect this approach. Epigenetic clocks are really interesting too (see Steve Horvath's work). Also, there's synthetic biology, where you could, for example, explore this package that's written in Go: https://github.com/TimothyStiles/poly

Check out poly. It’s written in go and I’m using it for one of my projects too. The goal is that we should have high performance libraries that we can use knowing what people are working on the forks will give the community a leg up.

The most popular bioinformatic package I've seen in go is poly.

I write synthetic biology software for a living and maintain this open source, Go package for engineering DNA that has high test coverage and a nice little dev community around it.

https://github.com/TimothyStiles/poly

A large part of my project's community are devs that want to get into the field but can't tolerate the ridiculously low pay, laughably bad management, disrespect, and what amounts to 40+ years of technical debt that's endemic to biotech software.

I've had companies here in the Bay Area offer me 100K a year with a straight face. I've had companies during interview tell me they're looking for someone to help, "set up GitHub". I've seen job listings for low paid web dev positions require applicants to have PhDs.

The reality is that except for a growing handful of places management straight up won't know the difference between IT and software engineers. It's what I call the naive buyers problem.

The demand for software engineers in biotech is generated by naive buyers that don't know what they need, why they need it, or how to get it.

Benchling and Recursion Pharmaceuticals have reputations in the industry of paying, "standard software salaries". So do the research divisions at places like deepmind/microsoft/google but in my experience there's even new multi-billion dollar institutes where senior management has never even heard the term devops.

Most places advertise for "data scientist", positions or some analog, instead of software engineers. This is mostly because upper management has never met an actual practicing software engineer in a professional setting. Many come from academia where the culture and work requirements heavily disincentivize standard software engineering practices.

It's also not uncommon for a biotech company to either have a very under qualified CTO whose main programming experience is what they learned doing ML research like stuff during their PhD or not even have one at all which has huge downstream consequences.

This week a software engineer trying to make the switch to biotech actually DM'd me to ask why they were seeing a ton of data science / ML job positions but no software engineering / devops positions.

They were worried that these companies were trying to save on costs by forcing their data scientists to create infrastructure but it's actually worse than that. Most of these companies aren't even aware that there's supposed to be infrastructure.

Despite all of this the future is looking better and I'm starting to find new companies and positions that are well... reasonable. I learned about this thread from a friend at a party last night that works at one of these companies. There's a small, strong new wave of companies and developers out there pushing biotech software forward. Hopefully some (including myself) make it big while pushing the idea that better tech equals better biotech.

It is more like the X Y Z W. However, the X Y Z W bits I am working on as well (https://github.com/TimothyStiles/poly , https://github.com/TimothyStiles/allbase , trilo.bio, freegenes.org). Going for fully automated "make bacterium X produce molecule Y", but still a while away (but surprisingly not THAT far off)

When I work with HTMX I need isolated component that can be reusable a form. So I create a PHP Function that generate the Input Datalist.

I was inspired by htmz (which was in turn inspired by htmx) and how the author got pretty close to a basic htmx-like experience just using an iframe. I wanted to push it a little further so whipped this demo together. My submission demonstrates progressive enhancement for the form - with js enabled the request targets an iframe that is inserted into the dom, meaning the page doesn't actually navigate (similar to event.preventDefault()). The iframe receives the html response from the request and on load triggers a function to swap out it's contents into the main page.

As described on htmx.org: "htmx gives you access to AJAX, CSS Transitions, WebSockets and Server Sent Events directly in HTML, using attributes, so you can build modern user interfaces with the simplicity and power of hypertext"

Apart from the source code itself, the repo's README also gives a bit more details about the various packages I used.

1. htmx: https://htmx.org/

Also, there’s some response header juggling you have to do when submitting forms that have a validation step before redirecting: https://github.com/bigskysoftware/htmx/issues/369

I’ve tried to iron out any footguns or server requirements I’ve bumped into while using HTMX & Hotwire in my projects.

✨ In recent months, I have been developing web projects using GOTTHA stack: Go + Templ + Tailwind CSS + htmx + Alpine.js. As soon as I'm ready to talk about all the subtleties and pitfalls, I'll post it on my social networks.

I've been digging into HTMX lately (using Python web frameworks) and find the concepts and approach to be interesting and promising. The idea of hypermedia driven systems over the current practice of JavaScript based frameworks (I never really got into React, played with Vue, and enjoy Svelte/SvelteKit) and the ability to chose your language/framework for the backend while primarily leveraging HTML/CSS on the frontend just seems refreshing.

Apparently it changed from 2-clause BSD: https://github.com/bigskysoftware/htmx/commit/e16f1865a494b6...

(The zero clause license drops the requirements for preserving the copyright notice when distributing)

It would be a sin not to start with something that prides itself on being the front-end library of peace. HTMX skyrocketed in popularity in 2023, gaining most of its GitHub stars during the past year. HTMX is not your average JS framework. If you work in HTMX, you will spend most of your time in the world of hypermedia, looking at web development from a completely different pair of eyes as compared to our usual JS-heavy outlook on modern web development. HTMX leverages the power of the concept of HATEOAS (Hypermedia as the Engine of Application State), enabling developers to access browser features directly from HTML, instead of using Javascript.