Hail VS FrameworkBenchmarks

I don't have any funding to hire right now, but I'm always happy to chat about the industry and my experience building Hail (https://hail.is, https://github.com/hail-is/hail), a tool widely used by folks with large collections of human sequences.

The other posters are not wrong about compensation. Total compensation is off by a factor of two to three.

However, it is absolutely possible to work with a group of top-notch engineers on serious distributed systems & compilers in service of an excellent scientific-user experience. I know because I do. We are lucky to have a PI who respects and hires and diversity of expertise within his lab.

I enjoy being deeply embedded with our users. I do not have to guess what they need or want because I help them do it every day.

I also enjoy enmeshing engineering with statistics, mathematics, and biology. Work is more interesting when so many disciplines conspire towards the end of improved human health.

I think this post is identifying scientific computing with simulation studies and legacy workflows, to a fault. Scientific computing includes those things, but it also includes interactive analysis of very large datasets as well as workflows designed around cloud computing.

Interactive analysis of large datasets (e.g. genome & exome sequencing studies with 100s of 1000s of samples) is well suited to low-latency, server-less, & horizontally scalable systems (like Dremel/BigQuery, or Hail [1], which we build and is inspired by Dremel, among other systems). The load profile is unpredictable because after a scientist runs an analysis they need an unpredictable amount of time to think about their next step.

As for productionized workflows, if we redesign the tools used within these workflows to directly read and write data to cloud storage as well as to tolerate VM-preemption, then we can exploit the ~1/5 cost of preemptible/spot instances.

One last point: for the subset of scientific computing I highlighted above, speed is key. I want the scientist to stay in a flow state, receiving feedback from their experiments as fast as possible, ideally within 300 ms. The only way to achieve that on huge datasets is through rapid and substantial scale-out followed by equally rapid and substantial scale-in (to control cost).

[1] https://hail.is

Broad Institute of MIT and Harvard | Cambridge, MA | Associate Software Engineer | Onsite

We are seeking an associate software engineer interested in contributing to an open-source data visualization library for analyzing the biological impact human genetic variation. You will contribute to projects like gnomAD (https://gnomad.broadinstitute.org), the world's largest catalogue of human genetic variation used by hundreds of thousands of researchers and help us scale towards millions of genomes in the coming years. We are also developing next-generation tools for enabling genetic analyses of large biobanks across richly phenotyped individuals (https://genebass.org). In this role you will gain experience developing data-intensive web applications with Typescript, React, Python, Terraform, Google Cloud Platform, and will make use of the scalable data analysis library Hail (https://hail.is). Key to our success is growing a strong team with a diverse membership who foster a culture of continual learning, and who support the growth and success of one another. Towards this end, we are committed to seeking applications from women and from underrepresented groups. We know that many excellent candidates choose not to apply despite their capabilities; please allow us to enthusiastically counter this tendency.

Please provide a CV and links previous work or projects, ideally with contributions visible on Github.

email: [email protected]

Neat. Thanks for sharing!

Interestingly, may-minihttp is faring very well in the TechEmpower benchmark [1], for whatever those benchmarks are worth. The code is also surprisingly straightforward [2].

[1] https://www.techempower.com/benchmarks/

[2] https://github.com/TechEmpower/FrameworkBenchmarks/blob/mast...

ntex was formed after a schism in actix-web and Rust safety/unsafety, with ntex allowing more unsafe code for better performance.

ntex is at the top of the TechEmpower benchmarks, although those benchmarks are not apples-to-apples since each uses its own tricks: https://www.techempower.com/benchmarks/#hw=ph&test=fortune&s...

Ruby is slow. Very slow. How much you may ask? https://www.techempower.com/benchmarks/#hw=ph&test=fortune&s... fastest Ruby entry is at 272th place. Sure, top entries tend to have questionable benchmark-golfing implementations, but it gives you a good primer on the overhead imposed by Ruby.

It is also not early 00s anymore, when you pick an interpreted language, you are not getting "better productivity and tooling". In fact, most interpreted languages lag behind other major languages significantly in the form of JS/TS, Python and Ruby suffering from different woes when it comes to package management and publishing. I would say only TS/JS manages to stand apart with being tolerable, and Python sometimes too by a virtue of its popularity and the amount of information out there whenever you need to troubleshoot.

If you liked Go but felt it being a too verbose to your liking, give .NET a try. I am advocating for it here on HN mostly for fun but it is, in fact, highly underappreciated, considered unsexy and boring while it's anything but after a complete change of trajectory in the last 3-5 years. It is actually the* stack people secretly want but simply don't know about because it is bundled together with Java in the public perception.

*productive CLI tooling, high performance, works well in a really wide range of workloads from low to high level, by far the best ORM across all languages and back-end framework that is easier to work with than Node.JS while consuming 0.1x resources

Although that seems to have improved in recent years.

https://www.techempower.com/benchmarks/#hw=ph&test=json§...

RoR and whatever C++ based web backend there is count as a valid comparison in my book. But comparing the languages itself is maybe a bit off.

On a side note, you can actually compare their performance here if you’re really curious. But take it with a grain of salt since these are synthetic benchmarks.

https://www.techempower.com/benchmarks

Most benchmarks you'll find essentially have someone's thumb on the scale (intentionally or unintentionally). Most people won't know the different languages well enough to create comparable implementations and if you let different people create the implementations, cheating happens. The TechEmpower benchmarks aren't bad, but many implementations put their thumb on the scale (https://www.techempower.com/benchmarks). For example, a lot of the Go implementations avoid the GC by pre-allocating/reusing structs or allocate arrays knowing how big they need to be in advance (despite that being against the rules). At some point, it becomes "how many features have you turned off." Some Go http routers (like fasthttp and those built off it like Atreugo and Fiber) aren't actually correct and a lot of people in the Go community discourage their use, but they certainly top the benchmarks. Gin and Echo are usually the ones that are well-respected in the Go community.

There is certainly a lot of speculation in Techempower benchmarks and top entries can utilize questionable techniques like simply writing a byte array literal to output stream instead of constructing a response, or (in the past) DB query coalescing to work around inherent limitations of the DB in case of Fortunes or DB quries.

And yet, the fastest Ruby entry is at 274th place while Rails is at 427th.

https://www.techempower.com/benchmarks/#hw=ph&test=fortune&s...

oh what machine? with how many workers? doing what?

search for "node" on this page: https://www.techempower.com/benchmarks/#section=data-r21

JustJS would like a word https://www.techempower.com/benchmarks/#section=data-r20&tes...

In terms of RPS, this web service is more-or-less the fortunes benchmark in the techempower benchmarks, once the data hits the cache: https://www.techempower.com/benchmarks/#section=data-r21

Or, at least, they would be after applying optimizations to them.

In short, both of these would serve more rps than you will likely ever need on even the lowest end virtual machines. The underlying API provider will probably cut you off from querying them before you run out of RPS.